From Memios
The Longevity Letter
Practical writing and video on living strong and active into your 90s. No hype, no supplements to sell. Just what the evidence supports and what it looks like on an ordinary Tuesday.
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MedicationsLevothyroxine
Well established. It replaces missing thyroid hormone.
2026-09-29 · 15 min read
MedicationsLisdexamfetamine
It raises brain dopamine and noradrenaline signalling through the dextroamphetamine released from it.
2026-09-29 · 20 min read
MedicationsLisinopril
Well established. Lisinopril lowers blood pressure.
2026-09-29 · 19 min read
MedicationsLoratadine
Loratadine blocks peripheral H1 histamine receptors, reducing the sneezing, itching and runny nose of allergic reactions, while penetrating the brain only minimally so it is comparatively non-sedating.
2026-09-29 · 11 min read
MedicationsLorazepam
Well established. Lorazepam sedates and damps down anxiety, and it stops seizures.
2026-09-29 · 14 min read
MedicationsLosartan
Well established. Losartan lowers blood pressure.
2026-09-29 · 21 min read
MedicationsMeloxicam
Well established. In 12-week placebo-controlled trials it improved arthritis symptoms at 7.5 and 15 mg.
2026-09-29 · 10 min read
MedicationsMetformin
In UKPDS 34, overweight people with newly diagnosed type 2 diabetes who were allocated metformin had fewer diabetes-related endpoints and lower all-cause mortality than those on diet alone.
2026-09-29 · 17 min read
MedicationsMethylphenidate
Cochrane reviews find it may reduce ADHD symptoms in children and modestly reduces self-rated symptoms in adults, but rate the certainty of evidence very low, with mostly short, often industry-sponsored trials.
2026-09-29 · 10 min read
MedicationsMetoprolol
Well established. The strength of the evidence depends heavily on why it is prescribed.
2026-09-29 · 17 min read
MedicationsMontelukast
Well established. It blocks the CysLT1 receptor, where leukotrienes act to narrow and inflame the airways.
2026-09-29 · 10 min read
MedicationsOlmesartan
For lowering blood pressure the class evidence is solid and olmesartan is not distinguishable from other ARBs.
2026-09-29 · 19 min read
MedicationsOmeprazole
The trial evidence that PPIs relieve heartburn and help heal and prevent ulcers (with antibiotics when H. pylori is present) is solid, though Cochrane rates much of the ulcer evidence low quality.
2026-09-29 · 15 min read
MedicationsOndansetron
Well established. Ondansetron blocks the serotonin signal that vomiting is triggered by.
2026-09-29 · 18 min read
MedicationsOxycodone
It relieves pain by acting on opioid receptors in the brain and spinal cord, with no ceiling to the dose-response for analgesia.
2026-09-29 · 26 min read
MedicationsPantoprazole
The best evidence is for healing erosive oesophagitis (acid damage to the gullet): in a Wyeth-funded placebo-controlled trial, 88% of people on 40 mg had healed at 8 weeks versus 33% on placebo.
2026-09-29 · 12 min read
MedicationsPotassium Chloride
Well established. Its approved job is to raise potassium in people who are low, or to stop them going low.
2026-09-29 · 23 min read
MedicationsPrednisone
It enters cells and switches specific genes on and off, which damps inflammation and the immune response.
2026-09-29 · 13 min read
MedicationsRosuvastatin
Rosuvastatin lowers LDL cholesterol substantially: by 50% at 20 mg in JUPITER and 26.5% at 10 mg in HOPE-3.
2026-09-29 · 15 min read
MedicationsSertraline
In the largest network meta-analysis (522 trials), all antidepressants beat placebo for acute depression in adults, and sertraline was among the better tolerated.
2026-09-29 · 13 min read
MedicationsSimvastatin
In people with heart disease, simvastatin reduced death: in 4S all-cause mortality fell from 11.5% to 8.2% over about 5.4 years, and in HPS from 14.7% to 12.9% over 5 years.
2026-09-29 · 12 min read
MedicationsTamsulosin
In the two pivotal 13-week US placebo-controlled trials (1,486 men) urinary symptom scores improved more on tamsulosin than placebo, though placebo groups also improved substantially.
2026-09-29 · 12 min read
MedicationsTestosterone
Where a man genuinely has low testosterone from testicular or pituitary disease, replacement raises the hormone level and improves sexual function and quality of life; that part is consistently found in meta-analyses.
2026-09-29 · 17 min read
MedicationsTizanidine
Limited evidence. The evidence is thin for its size of use.
2026-09-29 · 18 min read