From Memios
The Longevity Letter
Practical writing and video on living strong and active into your 90s. No hype, no supplements to sell. Just what the evidence supports and what it looks like on an ordinary Tuesday.
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MedicationsTamsulosin
In the two pivotal 13-week US placebo-controlled trials (1,486 men) urinary symptom scores improved more on tamsulosin than placebo, though placebo groups also improved substantially.
2026-09-29 · 12 min read
MedicationsTestosterone
Where a man genuinely has low testosterone from testicular or pituitary disease, replacement raises the hormone level and improves sexual function and quality of life; that part is consistently found in meta-analyses.
2026-09-29 · 17 min read
SupplementsThiamin
Thiamin is essential, and deficiency causes beriberi and Wernicke-Korsakoff syndrome, especially in heavy drinkers and after bariatric surgery.
2026-09-29 · 8 min read
MedicationsTizanidine
Limited evidence. The evidence is thin for its size of use.
2026-09-29 · 18 min read
MedicationsTopiramate
Well established. For the two uses it is licensed for, the randomised evidence is good.
2026-09-29 · 31 min read
MedicationsTramadol
Tramadol is approved for pain, but the outcome evidence for chronic pain is weaker than its wide use suggests.
2026-09-29 · 24 min read
MedicationsTrazodone
Limited evidence. Its effects depend on dose.
2026-09-29 · 11 min read
Fasting14:10 time-restricted eating
Limited evidence. Evidence is limited.
2026-09-29 · 9 min read
Fasting20:4 time-restricted eating
One 8-week randomised trial in adults with obesity found that 4-hour eating (3 to 7 p.m.) reduced weight by about 3%, insulin resistance and oxidative stress versus controls.
2026-09-29 · 10 min read
MedicationsTriamcinolone
Disputed. The evidence differs sharply by route, so the routes have to be judged separately.
2026-09-29 · 16 min read
SupplementsTribulus terrestris
Disputed. Despite the marketing, the evidence for a testosterone effect is essentially absent.
2026-09-29 · 17 min read
SupplementsTurmeric and curcumin
Disputed. The claim is that curcumin is anti-inflammatory and helps joints, mood and blood sugar.
2026-09-29 · 13 min read
SupplementsUrolithin A
Limited evidence. The honest summary is that human evidence is thin and mostly inconclusive.
2026-09-29 · 15 min read
MedicationsValacyclovir
The state of the evidence is that valacyclovir shortens and reduces herpes outbreaks and, taken daily, lowers how often outbreaks happen and how often an infected partner passes genital herpes to someone else.
2026-09-29 · 14 min read
MedicationsValsartan
The evidence is strongest for what valsartan does to numbers and to hospitalisations rather than to survival.
2026-09-29 · 18 min read
MedicationsVenlafaxine
Well established. The strongest evidence is for major depressive disorder and generalised anxiety disorder.
2026-09-29 · 21 min read
SupplementsVitamin A
Vitamin A is needed for vision, immune function, growth and reproduction. In children at risk of deficiency, a meta-analysis of 43 trials found supplementation cut all-cause mortality by about 24%.
2026-09-29 · 9 min read
SupplementsVitamin B6
B6 in its coenzyme forms takes part in more than 100 enzyme reactions, mostly in protein metabolism.
2026-09-29 · 10 min read
SupplementsVitamin D
Disputed. The strongest human evidence is negative rather than positive.
2026-09-29 · 17 min read
SupplementsVitamin E
Large trials have mostly failed to show benefit from vitamin E supplements, and several found harm.
2026-09-29 · 12 min read
SupplementsVitamin K2
The evidence is thin and much of the positive fracture data comes from Japanese trials of MK-4.
2026-09-29 · 12 min read
MedicationsWarfarin
Warfarin blocks an enzyme the liver needs to activate vitamin K, which reduces the liver's production of several clotting factors and thins the blood over several days.
2026-09-29 · 15 min read
SupplementsWheatgrass and barley grass
Not supported by the research. Very little human trial evidence exists.
2026-09-29 · 8 min read
SupplementsWhey protein
What the trials support is protein supplementation in general alongside resistance training, not whey specifically.
2026-09-29 · 14 min read