From Memios
The Longevity Letter
Practical writing and video on living strong and active into your 90s. No hype, no supplements to sell. Just what the evidence supports and what it looks like on an ordinary Tuesday.
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SupplementsLacticaseibacillus rhamnosus GG
The best evidence is for reducing antibiotic-associated diarrhoea in children (moderate-quality pooled evidence); in adults the pooled result was not significant.
2026-09-29 · 11 min read
MedicationsLatanoprost
The evidence is that latanoprost reliably lowers pressure inside the eye, and that in one placebo-controlled trial this slowed the loss of visual field in newly diagnosed open-angle glaucoma over two years.
2026-09-29 · 13 min read
MedicationsLevothyroxine
Well established. It replaces missing thyroid hormone.
2026-09-29 · 15 min read
SupplementsLicorice root
Limited evidence. The best evidence concerns harm.
2026-09-29 · 11 min read
SupplementsLion's mane
The honest summary is that almost all of the biology behind lion's mane's reputation is cell-culture and rodent work, and the human evidence is a handful of small, short trials with inconsistent results.
2026-09-29 · 20 min read
MedicationsLisdexamfetamine
It raises brain dopamine and noradrenaline signalling through the dextroamphetamine released from it.
2026-09-29 · 20 min read
MedicationsLisinopril
Well established. Lisinopril lowers blood pressure.
2026-09-29 · 19 min read
MedicationsLoratadine
Loratadine blocks peripheral H1 histamine receptors, reducing the sneezing, itching and runny nose of allergic reactions, while penetrating the brain only minimally so it is comparatively non-sedating.
2026-09-29 · 11 min read
MedicationsLorazepam
Well established. Lorazepam sedates and damps down anxiety, and it stops seizures.
2026-09-29 · 14 min read
MedicationsLosartan
Well established. Losartan lowers blood pressure.
2026-09-29 · 21 min read
SupplementsLutein and zeaxanthin
Limited evidence. The evidence is limited and mostly about the eye.
2026-09-29 · 20 min read
SupplementsLycopene
Limited evidence. Less is established than the marketing suggests.
2026-09-29 · 15 min read
SupplementsManganese
Limited evidence. Manganese is essential, but deficiency is not a concern in people eating normal diets.
2026-09-29 · 9 min read
SupplementsMelatonin
Limited evidence. The honest summary is that melatonin's measured effect on sleep is real but small.
2026-09-29 · 18 min read
MedicationsMeloxicam
Well established. In 12-week placebo-controlled trials it improved arthritis symptoms at 7.5 and 15 mg.
2026-09-29 · 10 min read
MedicationsMetformin
In UKPDS 34, overweight people with newly diagnosed type 2 diabetes who were allocated metformin had fewer diabetes-related endpoints and lower all-cause mortality than those on diet alone.
2026-09-29 · 17 min read
MedicationsMethylphenidate
Cochrane reviews find it may reduce ADHD symptoms in children and modestly reduces self-rated symptoms in adults, but rate the certainty of evidence very low, with mostly short, often industry-sponsored trials.
2026-09-29 · 10 min read
SupplementsMethylsulfonylmethane
Limited evidence. The evidence is limited.
2026-09-29 · 17 min read
MedicationsMetoprolol
Well established. The strength of the evidence depends heavily on why it is prescribed.
2026-09-29 · 17 min read
ResearchWhat happens to the gut microbiome during and after a course of antibiotics?
A disrupted community is measured, not felt: sequencing shows loss of diversity within 3 to 4 days of starting a drug and a shifted composition afterwards.
2026-09-29 · 7 min read
SupplementsMilk thistle
Milk thistle is the archetypal liver supplement, and the liver evidence is the weakest part of its file.
2026-09-29 · 16 min read
FastingModified alternate-day fasting
Well established. Modified ADF leads to weight loss compared with no diet change.
2026-09-29 · 11 min read
SupplementsMolybdenum
Molybdenum is needed for a small set of enzymes, and dietary deficiency has never been seen in healthy people; the only acquired deficiency on record was a patient fed intravenously without it.
2026-09-29 · 7 min read
MedicationsMontelukast
Well established. It blocks the CysLT1 receptor, where leukotrienes act to narrow and inflame the airways.
2026-09-29 · 10 min read