From Memios
The Longevity Letter
Practical writing and video on living strong and active into your 90s. No hype, no supplements to sell. Just what the evidence supports and what it looks like on an ordinary Tuesday.
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SupplementsN-acetylcysteine
Limited evidence. The best-graded evidence is narrow.
2026-09-29 · 14 min read
SupplementsNattokinase
The evidence is limited and mostly about surrogate markers, not about heart attacks or strokes.
2026-09-29 · 13 min read
SupplementsNiacin
Not supported by the research. The strongest evidence is against the main claim made for high-dose nicotinic acid.
2026-09-29 · 11 min read
SupplementsNAD+ precursors: nicotinamide mononucleotide
Short human trials show these compounds are well tolerated but have not shown consistent clinical benefit.
2026-09-29 · 13 min read
SupplementsNoni
Limited evidence. Noni is marketed as an antioxidant, immune-supporting and anticancer supplement.
2026-09-29 · 12 min read
SupplementsOat and barley beta-glucan
Well established. Beta-glucan lowers LDL cholesterol.
2026-09-29 · 9 min read
SupplementsOlive leaf extract
Limited evidence. The evidence is real but thin and low-certainty.
2026-09-29 · 15 min read
MedicationsOlmesartan
For lowering blood pressure the class evidence is solid and olmesartan is not distinguishable from other ARBs.
2026-09-29 · 19 min read
FastingOne meal a day
The evidence is thin: three small crossover trials in healthy normal-weight adults (two reports from one trial, lasting 8 weeks per period, and one 11-day trial) and one observational cohort.
2026-09-29 · 9 min read
SupplementsOmega-3 fatty acids
This is the ingredient where the marketing and the trial evidence part company most sharply.
2026-09-29 · 22 min read
MedicationsOmeprazole
The trial evidence that PPIs relieve heartburn and help heal and prevent ulcers (with antibiotics when H. pylori is present) is solid, though Cochrane rates much of the ulcer evidence low quality.
2026-09-29 · 15 min read
MedicationsOndansetron
Well established. Ondansetron blocks the serotonin signal that vomiting is triggered by.
2026-09-29 · 18 min read
MedicationsOxycodone
It relieves pain by acting on opioid receptors in the brain and spinal cord, with no ceiling to the dose-response for analgesia.
2026-09-29 · 26 min read
SupplementsPanax notoginseng
The clinical evidence is large in volume but weak in quality, and almost all of it comes from China.
2026-09-29 · 16 min read
MedicationsPantoprazole
The best evidence is for healing erosive oesophagitis (acid damage to the gullet): in a Wyeth-funded placebo-controlled trial, 88% of people on 40 mg had healed at 8 weeks versus 33% on placebo.
2026-09-29 · 12 min read
SupplementsPantothenic acid
The evidence for supplements is thin. Pantethine, a related compound, lowered LDL cholesterol by about 11% in one small 16-week trial of 32 people.
2026-09-29 · 7 min read
SupplementsPapain and papaya enzyme
Limited evidence. There is very little human evidence.
2026-09-29 · 6 min read
SupplementsParaxanthine
Paraxanthine is a stimulant with pharmacology similar to caffeine, which is unsurprising since it is what most caffeine turns into.
2026-09-29 · 16 min read
SupplementsPhosphatidylserine
The evidence is disputed and the older positive results mostly used a form no longer sold.
2026-09-29 · 16 min read
SupplementsPolicosanol
This is one of the sharpest disagreements in the supplement literature, and it splits by who ran the trial.
2026-09-29 · 12 min read
SupplementsPomegranate
The strongest evidence is for a small average reduction in blood pressure: a 2026 meta-analysis of 33 clinical trials pooled a fall of about 3.5 mmHg systolic and 1.5 mmHg diastolic.
2026-09-29 · 18 min read
MedicationsPotassium Chloride
Well established. Its approved job is to raise potassium in people who are low, or to stop them going low.
2026-09-29 · 23 min read
SupplementsPotassium
Well established. Potassium is needed to keep fluid volume and electrical gradients across cell membranes.
2026-09-29 · 12 min read
MedicationsPrednisone
It enters cells and switches specific genes on and off, which damps inflammation and the immune response.
2026-09-29 · 13 min read