From Memios
The Longevity Letter
Practical writing and video on living strong and active into your 90s. No hype, no supplements to sell. Just what the evidence supports and what it looks like on an ordinary Tuesday.
579 items
SupplementsCitrus bioflavonoids
Disputed. The evidence conflicts.
2026-09-29 · 9 min read
MedicationsClonazepam
Limited evidence. The evidence is uneven and mostly short-term.
2026-09-29 · 19 min read
MedicationsClonidine
Clonidine lowers blood pressure and calms the noradrenaline surge that drives opioid withdrawal, and it reduces the core symptoms of ADHD.
2026-09-29 · 19 min read
MedicationsClopidogrel
Clopidogrel reduces heart attacks, strokes and cardiovascular deaths in people who already have arterial disease, and it increases bleeding.
2026-09-29 · 14 min read
ResearchClostridioides difficile infection after antibiotics: risk by drug class, prevention and outcomes
Pooled observational data show large differences in risk by drug class, with clindamycin, fluoroquinolones and cephalosporin-type drugs carrying the highest odds and tetracyclines showing no increase.
2026-09-29 · 9 min read
SupplementsCoenzyme Q10
CoQ10 is marketed mainly for two things: protecting muscles from statin side effects, and helping a failing heart.
2026-09-29 · 16 min read
SupplementsCollagen peptides
The evidence here is unusual: several meta-analyses report statistically significant benefits.
2026-09-29 · 15 min read
SupplementsColloidal silver
Not supported by the research. There is no established use for swallowed colloidal silver.
2026-09-29 · 14 min read
ResearchWhat consumer stool microbiome tests can and cannot tell you
They are marketed as reading your gut health; the published evaluations say the analytical performance does not yet support that.
2026-09-29 · 14 min read
SupplementsCopper
Copper is essential, and deficiency causes anaemia, low white cells and nerve damage that copper can correct.
2026-09-29 · 8 min read
SupplementsCordyceps
Limited evidence. Evidence is limited and inconsistent.
2026-09-29 · 10 min read
MedicationsDapagliflozin
This is one of the better-evidenced drugs in modern medicine for its cardiac and kidney uses, resting on large placebo-controlled outcome trials rather than surrogate markers.
2026-09-29 · 23 min read
MedicationsDextroamphetamine; Amphetamine
In short-term trials, amphetamines reduce clinician-rated ADHD symptoms more than placebo in both children and adults, with large effects on average.
2026-09-29 · 13 min read
SupplementsDHEA
Disputed. The evidence is mixed and mostly disappointing.
2026-09-29 · 17 min read
MedicationsDiclofenac
Diclofenac is among the most effective oral anti-inflammatory painkillers and among the most cardiovascularly risky.
2026-09-29 · 24 min read
ResearchHow does dietary fibre affect the gut microbiome and health?
Across 64 trials, fibre supplements (especially fructans and galacto-oligosaccharides) raised stool Bifidobacterium and Lactobacillus but did not change alpha-diversity.
2026-09-29 · 9 min read
SupplementsDigestive enzyme blends
For people whose pancreas does not make enough enzymes (exocrine pancreatic insufficiency, for example in cystic fibrosis), prescription enzyme replacement is the standard treatment.
2026-09-29 · 7 min read
SupplementsDPP IV protease and gluten-degrading enzyme supplements
Common DPP-IV-type digestive enzyme supplements do not protect people with coeliac disease: laboratory testing found they leave the immune-triggering parts of gluten largely intact.
2026-09-29 · 11 min read
MedicationsDulaglutide
In the REWIND trial (9,901 people, median 5.4 years) it reduced the combined rate of heart attack, stroke and cardiovascular death from 13.4% to 12.0%, a hazard ratio of 0.88, while all-cause mortality did not differ.
2026-09-29 · 15 min read
MedicationsDuloxetine
Well established. It blocks the reabsorption of the brain chemicals serotonin and norepinephrine.
2026-09-29 · 17 min read
FastingEat-Stop-Eat
Limited evidence. Evidence for weekly 24-hour fasting is limited to one small RCT.
2026-09-29 · 9 min read
SupplementsEchinacea
Disputed. The evidence is disputed rather than settled.
2026-09-29 · 13 min read
SupplementsElderberry
The honest summary is that the evidence is thin and uncertain rather than settled either way.
2026-09-29 · 14 min read
SupplementsEleuthero
Not supported by the research. It is sold as an 'adaptogen' for stress, fatigue and stamina.
2026-09-29 · 10 min read