From Memios
The Longevity Letter
Practical writing and video on living strong and active into your 90s. No hype, no supplements to sell. Just what the evidence supports and what it looks like on an ordinary Tuesday.
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SupplementsBurdock root
Limited evidence. It is sold as a detox or 'blood purifier' tea and for skin, joints and blood sugar.
2026-09-29 · 8 min read
MedicationsBuspirone
A Cochrane review of 36 trials in 5,908 people found azapirones including buspirone better than placebo for generalised anxiety disorder, with a number needed to treat of 4.4 on the Clinical Global Impression scale.
2026-09-29 · 19 min read
SupplementsButterbur
Disputed. The evidence is narrow and contested.
2026-09-29 · 18 min read
SupplementsCaffeine
The evidence is strongest for the things caffeine does acutely: it raises alertness, and added to a standard painkiller it gives a small extra amount of pain relief with high-certainty evidence from Cochrane.
2026-09-29 · 22 min read
SupplementsCalcium
Supplements raise bone density slightly and, in pooled trials, cut total fractures by about a tenth.
2026-09-29 · 13 min read
MedicationsCarvedilol
Well established. It slows the heart and relaxes blood vessels by blocking adrenaline's effects.
2026-09-29 · 12 min read
MedicationsCelecoxib
Celecoxib relieves pain and inflammation, and the size of that relief is modest and measurable.
2026-09-29 · 20 min read
MedicationsCephalexin
For the infections it is licensed for, the trial evidence is reasonably good but narrower than the label suggests.
2026-09-29 · 23 min read
MedicationsCetirizine hydrochloride
For allergic rhinitis, network meta-analysis of randomised trials shows oral antihistamines as a class beat placebo on symptom scores, with cetirizine among the more effective agents but not the top-ranked one.
2026-09-29 · 14 min read
SupplementsChlorella
The human evidence is a set of small, mostly short randomized trials pooled in meta-analyses.
2026-09-29 · 10 min read
MedicationsCholecalciferol
Correcting deficiency is where the evidence is solid: vitamin D sufficiency prevents rickets in children and osteomalacia in adults.
2026-09-29 · 29 min read
SupplementsChondroitin sulfate
Disputed. The evidence is disputed.
2026-09-29 · 15 min read
SupplementsChromium
Disputed. The evidence is weak and contested.
2026-09-29 · 11 min read
SupplementsCinnamon
Disputed. The evidence is disputed rather than settled.
2026-09-29 · 16 min read
SupplementsCitrus bioflavonoids
Disputed. The evidence conflicts.
2026-09-29 · 9 min read
MedicationsClonazepam
Limited evidence. The evidence is uneven and mostly short-term.
2026-09-29 · 19 min read
MedicationsClonidine
Clonidine lowers blood pressure and calms the noradrenaline surge that drives opioid withdrawal, and it reduces the core symptoms of ADHD.
2026-09-29 · 19 min read
MedicationsClopidogrel
Clopidogrel reduces heart attacks, strokes and cardiovascular deaths in people who already have arterial disease, and it increases bleeding.
2026-09-29 · 14 min read
ResearchClostridioides difficile infection after antibiotics: risk by drug class, prevention and outcomes
Pooled observational data show large differences in risk by drug class, with clindamycin, fluoroquinolones and cephalosporin-type drugs carrying the highest odds and tetracyclines showing no increase.
2026-09-29 · 9 min read
SupplementsCoenzyme Q10
CoQ10 is marketed mainly for two things: protecting muscles from statin side effects, and helping a failing heart.
2026-09-29 · 16 min read
SupplementsCollagen peptides
The evidence here is unusual: several meta-analyses report statistically significant benefits.
2026-09-29 · 15 min read
SupplementsColloidal silver
Not supported by the research. There is no established use for swallowed colloidal silver.
2026-09-29 · 14 min read
ResearchWhat consumer stool microbiome tests can and cannot tell you
They are marketed as reading your gut health; the published evaluations say the analytical performance does not yet support that.
2026-09-29 · 14 min read
SupplementsCopper
Copper is essential, and deficiency causes anaemia, low white cells and nerve damage that copper can correct.
2026-09-29 · 8 min read