From Memios
The Longevity Letter
Practical writing and video on living strong and active into your 90s. No hype, no supplements to sell. Just what the evidence supports and what it looks like on an ordinary Tuesday.
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MedicationsTopiramate
Well established. For the two uses it is licensed for, the randomised evidence is good.
2026-09-29 · 31 min read
MedicationsTramadol
Tramadol is approved for pain, but the outcome evidence for chronic pain is weaker than its wide use suggests.
2026-09-29 · 24 min read
MedicationsTrazodone
Limited evidence. Its effects depend on dose.
2026-09-29 · 11 min read
MedicationsTriamcinolone
Disputed. The evidence differs sharply by route, so the routes have to be judged separately.
2026-09-29 · 16 min read
MedicationsValacyclovir
The state of the evidence is that valacyclovir shortens and reduces herpes outbreaks and, taken daily, lowers how often outbreaks happen and how often an infected partner passes genital herpes to someone else.
2026-09-29 · 14 min read
MedicationsValsartan
The evidence is strongest for what valsartan does to numbers and to hospitalisations rather than to survival.
2026-09-29 · 18 min read
MedicationsVenlafaxine
Well established. The strongest evidence is for major depressive disorder and generalised anxiety disorder.
2026-09-29 · 21 min read
MedicationsWarfarin
Warfarin blocks an enzyme the liver needs to activate vitamin K, which reduces the liver's production of several clotting factors and thins the blood over several days.
2026-09-29 · 15 min read